Mouse Monoclonal Antibody to DAXX | ProMab 20389 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to DAXX

catalog :

20389

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7A11

The same clone is also sold as:

Abcam: ab130198
OriGene: AM06368PU-N
Invitrogen: MA5-15552
Abnova: MAB10621

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, flow cytometry

product information

Catalog :

20389

Title :

Mouse Monoclonal Antibody to DAXX

Species :

Human

Clone :

7A11;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Immunogen :

Purified recombinant fragment of human DAXX expressed in E. Coli.

Formulation :

Antibody are purified by protein G affinity chromatography. ; Liquid in PBS containing 50% glycerol and 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Cell. 1997 Jun 27;89(7):1067-76. ; 2. Biochem Biophys Res Commun. 2000 Dec 9;279(1):6-10. ; 3. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.

Type :

Monoclonal Antibody

MW :

81kDa

Aliases :

DAP6; EAP1; BING2