ProMab

antibody

Mouse Monoclonal Antibody to TUBB3

20374

100μl

308.00 USD

monoclonal

mouse

2E9;

western blot, ELISA, immunocytochemistry, flow cytometry

20374

Mouse Monoclonal Antibody to TUBB3

Human

2E9;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

Tubulin, beta 3, also known as TUBB3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Tubulin is a highly conserved protein with a molecular weight of ~50 kD. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, α- and β-tubulin, are usually products of separate genes. The β-tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III β-tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia, and stem cell research. Class III β-tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy.

Purified recombinant fragment of human TUBB3 expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

1. Histopathology. 2007 Jun;50(7):949-52. ; 2. Neurochem Res. 2007 Aug;32(8):1387-98. ; 3. Exp Eye Res. 1995 Apr;60(4):385-400.

308.00 USD

Monoclonal Antibody

50kDa

tubulin, beta 3; MC1R; TUBB4