Mouse Monoclonal Antibody to Proteinase 3 | ProMab 20373 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Proteinase 3

catalog :

20373

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B4

The same clone is also sold as:

Invitrogen: MA5-15540
OriGene: AM06358PU-N
Abnova: MAB10304

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20373

Title :

Mouse Monoclonal Antibody to Proteinase 3

Species :

Human

Clone :

3B4;

lsotype :

Mouse IgG2b

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Immunogen :

Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Formulation :

Antibody are purified by protein G affinity chromatography. ; Liquid in PBS containing 50% glycerol and 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Blood. 2007 Dec 1;110(12):4086-95. ; 2. Clin Exp Immunol. 2006 Jul;145(1):63-70.

Type :

Monoclonal Antibody

MW :

28kDa

Aliases :

PRTN3; ACPA; CANCA