Mouse Monoclonal Antibody to NT5E | ProMab 20369 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to NT5E

catalog :

20369

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

#1D7

The same clone is also sold as:

Invitrogen: MA5-15537
OriGene: AM06357SU-N
Abnova: MAB10838

reactivity :

human

application :

immunohistochemistry

product information

Catalog :

20369

Title :

Mouse Monoclonal Antibody to NT5E

Species :

Human

Clone :

1D7;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.

Immunogen :

Purified recombinant fragment of NT5E expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; IHC: 1/200 - 1/1000

References :

1. Oncol Rep. 2007 Jun;17(6):1341-6. ; 2. Neurochem Int. 2003 Dec;43(7):621-8. ;

Type :

Monoclonal Antibody

MW :

70kDa

Aliases :

eN; NT5; CD73