Mouse Monoclonal Antibody to CK17 | ProMab 20363 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CK17

catalog :

20363

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B12

The same clone is also sold as:

Invitrogen: MA5-15534
OriGene: AM06354SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20363

Title :

Mouse Monoclonal Antibody to CK17

Species :

Human

Clone :

3B12;

lsotype :

Mouse IgG2b

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Immunogen :

Purified recombinant fragment of CK17 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Am J Pathol. 2002 Dec;161(6):1991-6. ; 2. Br J Dermatol. 1995 Oct;133(4):501-11. ;

Type :

Monoclonal Antibody

MW :

49kDa

Aliases :

PC; K17; PC2; PCHC1; KRT17