Mouse Monoclonal Antibody to MUSK | ProMab 20347 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MUSK

catalog :

20347

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10A4

The same clone is also sold as:

Abnova: MAB10428
MyBioSource: MBS850308
Novus Biologicals: NBP1-47441
OriGene: AM06338SU-N
Invitrogen: MA5-15518

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

product information

Catalog :

20347

Title :

Mouse Monoclonal Antibody to MUSK

Species :

Human

Clone :

10A4;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Immunogen :

Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. J Neuroimmunol. 2006 Aug;177(1-2):119-31. ; 2. Ann N Y Acad Sci. 2008;1132:76-83.

Type :

Monoclonal Antibody

MW :

97kDa

Aliases :

muscle, skeletal, receptor tyrosine kinase