Mouse Monoclonal Antibody to CD80 | ProMab 20341 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CD80

catalog :

20341

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2A2

The same clone is also sold as:

OriGene: AM06332SU-N
Invitrogen: MA5-15512
Abnova: MAB10424

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

product information

Catalog :

20341

Title :

Mouse Monoclonal Antibody to CD80

Species :

Human

Clone :

2A2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.

Immunogen :

Purified recombinant fragment of CD80 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. Transplant Proc. 2008 Oct;40(8):2729-33. ; 2. Nat Med. 2007 Dec;13(12):1440-9.

Type :

Monoclonal Antibody

MW :

55kDa

Aliases :

CD28LG; LAB7; B7.1