antibody

Mouse Monoclonal Antibody to FGFR4

20328

100μl

monoclonal

mouse

nonconjugated

7H1

The same clone is also sold as:

• Invitrogen: MA5-15500
• OriGene: AM06322SU-N
• Abnova: MAB10427

western blot, ELISA, immunocytochemistry

Mouse Monoclonal Antibody to FGFR4

Human

7H1;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.

Ascitic fluid containing 0.03% sodium azide. ;

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000

1. Br J Cancer. 2006 Jun 19;94(12):1879-86. ; 2. Diabetes. 2007 Oct;56(10):2501-10.

Monoclonal Antibody

87.9kDa

TKF; JTK2; CD334