antibody

Mouse Monoclonal Antibody to R-spondin1

20317

100μl

monoclonal

mouse

nonconjugated

'7A6

The same clone is also sold as:

• OriGene: AM06311SU-N
• Invitrogen: MA5-15489
• Abnova: MAB10360

western blot, ELISA

Mouse Monoclonal Antibody to R-spondin1

Human

7A6;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Purified recombinant fragment of R-spondin1 expressed in E. Coli. ;

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. Nat Genet. 2006 Nov;38(11):1304-9. ; 2. Hum Mutat. 2008 Feb;29(2):220-6.

Monoclonal Antibody

28.9kDa

RSPO1;CRISTIN3;FLJ40906