Mouse Monoclonal Antibody to CD45 | ProMab 20298 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to CD45

catalog :

20298

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A8A4C7A2

The same clone is also sold as:

OriGene: AM06301SU-N
Abnova: MAB10539
Invitrogen: MA5-15478

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20298

Title :

Mouse Monoclonal Antibody to CD45

Species :

Human

Clone :

4A8A4C7A2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

CD45, also known as TPRC(protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Immunogen :

Purified recombinant fragment of CD45 expressed in E. Coli. ; ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Biol Chem. 2008 May;389(5):561-8. ; 2. Immunology. 2008 Dec;125(4):558-69.

Type :

Monoclonal Antibody

Aliases :

LCA; LY5; B220; CD45; T200; CD45R; GP180; PTPRC