antibody

Mouse Monoclonal Antibody to STAT3

20293

100μl

monoclonal

mouse

nonconjugated

7G3H4

The same clone is also sold as:

• OriGene: AM06296SU-N
• Invitrogen: MA5-15473
• Abnova: MAB10413

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to STAT3

Human

7G3H4;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

STAT3: signal transducer and activator of transcription 3 (acute-phase response factor). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Purified recombinant fragment of STAT3 expressed in E. Coli. ;

Ascitic fluid containing 0.03% sodium azide. ;

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1. APMIS. 2007 Dec;115(12):1331-43. ; 2. Oncol Rep. 2008 Sep;20(3):597-604.

Monoclonal Antibody

APRF; HIES