Mouse Monoclonal Antibody to Oct4 | ProMab 20291 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Oct4

catalog :

20291

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D10H6

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20291

Title :

Mouse Monoclonal Antibody to Oct4

Species :

Human

Clone :

1D10H6;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

Immunogen :

Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Cells Tissues Organs. 2006;184(3-4):105-16. ; 2. Int J Cancer. 2007 Apr 1;120(7):1598-602. ;

Type :

Monoclonal Antibody

MW :

38.5kDa

Aliases :

OCT3; OTF3; OTF4; MGC22487; POU5F1