Mouse Monoclonal Antibody to SKP2 | ProMab 20290 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to SKP2

catalog :

20290

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6G9D10

The same clone is also sold as:

Invitrogen: MA5-15470
OriGene: AM06294SU-N

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20290

Title :

Mouse Monoclonal Antibody to SKP2

Species :

Human

Clone :

6G9D10;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

SKP2: S-phase kinase-associated protein 2 (p45). This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms.

Immunogen :

Purified recombinant fragment of SKP2 (aa1-130) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide. ;

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Acta Biochim Biophys Sin (Shanghai). 2007 Dec;39(12):999-1007. ; 2. Clin Cancer Res. 2008 Apr 1;14(7):1966-75.

Type :

Monoclonal Antibody

Aliases :

FBL1; FLB1; FBXL1; MGC1366; SKP2