Mouse Monoclonal Antibody to F8 | ProMab 20278 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to F8

catalog :

20278

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5E9B2

The same clone is also sold as:

Invitrogen: MA5-15459
OriGene: AM06283SU-N

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20278

Title :

Mouse Monoclonal Antibody to F8

Species :

Human

Clone :

5E9B2;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Immunogen :

Purified recombinant fragment of F8 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Thromb Haemost. 2007 Nov;98(5):1031-9. ; 2. Blood. 2008 Apr 1;111(7):3468-78.

Type :

Monoclonal Antibody

Aliases :

AHF; F8B; F8C; HEMA; FVIII