antibody

Mouse Monoclonal Antibody to AR

20273

100μl

monoclonal

mouse

nonconjugated

1A9D12

The same clone is also sold as:

• Invitrogen: MA5-15455
• OriGene: AM06279SU-N

western blot, ELISA

Mouse Monoclonal Antibody to AR

Human

1A9D12;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Purified recombinant fragment of AR (aa689-919) expressed in E. Coli. ;

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. Cancer Res. 2006 Nov 15;66(22):11077-83. ; 2. Mol Cell Biol. 2007 Oct;27(20):7125-42.

Monoclonal Antibody

KD; AIS; TFM; DHTR; SBMA