antibody

Mouse Monoclonal Antibody to ERBB3

20254

100μl

monoclonal

mouse

nonconjugated

3F10F6

The same clone is also sold as:

• OriGene: AM06263SU-N
• Invitrogen: MA5-15437
• Abnova: MAB12609

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to ERBB3

Human

3F10F6;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1. Cancer Sci. 2007 Sep;98(9):1498-503. ; 2. Breast Cancer Res. 2008;10(1):R2.

Monoclonal Antibody

HER3; LCCS2