Mouse Monoclonal Antibody to ABL1 | ProMab 20244 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ABL1

catalog :

20244

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B11D6

The same clone is also sold as:

OriGene: AM06256SU-N
Invitrogen: MA5-15430

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20244

Title :

Mouse Monoclonal Antibody to ABL1

Species :

Human

Clone :

7B11D6;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Immunogen :

Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Cell. 2006 Nov 3;127(3):635-48. ; 2. Biochem Biophys Res Commun. 2007 Jan 12;352(2):431-6.

Type :

Monoclonal Antibody

Aliases :

ABL; JTK7; p150; c-ABL; v-abl