antibody

Mouse Monoclonal Antibody to DDR1

20242

100μl

monoclonal

mouse

nonconjugated

2G4E12

The same clone is also sold as:

• Abnova: MAB12603
• OriGene: AM06255SU-N, AM20432SU-N
• Invitrogen: MA5-15429
• Novus Biologicals: NBP1-28861-0.025ml

western blot, ELISA

Mouse Monoclonal Antibody to DDR1

Human

2G4E12;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli. ;

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. FASEB J. 2000 May;14(7):973-81. ; 2. Exp Eye Res. 2001 Jan;72(1):87-92. ; 3. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.

Monoclonal Antibody

CAK; DDR; NEP; PTK3; RTK6; TRKE; CD167