Mouse Monoclonal Antibody to PYK2 | ProMab 20212 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PYK2

catalog :

20212

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5E2D5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-130077
Invitrogen: MA5-15407
Abnova: MAB10359
OriGene: AM06233SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20212

Title :

Mouse Monoclonal Antibody to PYK2

Species :

Human

Clone :

5E2D5;

lsotype :

Mouse IgG2a

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Immunogen :

Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Exp Hematol. 2004 Apr;32(4):365-74. ; 2. J Cell Sci. 2004 May 15;117(Pt 12):2557-68. ; 3. Int J Cancer. 2005 Feb 20;113(5):689-98. ;

Type :

Monoclonal Antibody

MW :

115.8kDa

Aliases :

PKB; PTK; CAKB; FAK2; FRNK; PTK2B