Mouse Monoclonal Antibody to SYK | ProMab 20211 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to SYK

catalog :

20211

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8C1A3

The same clone is also sold as:

OriGene: AM06232SU-N
Invitrogen: MA5-15406

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20211

Title :

Mouse Monoclonal Antibody to SYK

Species :

Human

Clone :

8C1A3;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

Immunogen :

Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Blood. 2006 Nov 15;108(10):3352-9 ; 2. Int J Mol Med. 2006 Oct;18(4):547-57. ; 3. J Exp Med. 2006 Dec 25;203(13):2829-40.

Type :

Monoclonal Antibody

Aliases :

FLJ25043; FLJ37489; DKFZp313N1010