Mouse Monoclonal Antibody to MAPK10 | ProMab 20207 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MAPK10

catalog :

20207

quantity :

100μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10E4A4

The same clone is also sold as:

Abnova: MAB10598
Invitrogen: MA5-15403
Santa Cruz Biotechnology: sc-130075
OriGene: AM06230SU-N

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

product information

Catalog :

20207

Title :

Mouse Monoclonal Antibody to MAPK10

Species :

Human; Mouse

Clone :

10E4A4;

lsotype :

Mouse IgG1

Size :

100μl

Storage :

4℃; -20℃ for long term storage

Description :

MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen :

Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000

References :

1. Blood. 2002 Oct 1;100(7):2546-53 ; 2. J Leukoc Biol. 2003 May;73(5):682 ; 3. Exp Neurol. 2004 Aug;188(2):246 ;

Type :

Monoclonal Antibody

MW :

53kDa

Aliases :

JNK3; JNK3A; PRKM10; p54bSAPK