antibody

Mouse Monoclonal Antibody to GATA3

20187

100μl

monoclonal

mouse

nonconjugated

1A10D1

The same clone is also sold as:

• Santa Cruz Biotechnology: sc-130057 X, sc-130057
• OriGene: AM06216SU-N
• Invitrogen: MA5-15387

western blot, ELISA

Mouse Monoclonal Antibody to GATA3

Human

1A10D1;

Mouse IgG1

100μl

4℃; -20℃ for long term storage

GATA3: GATA binding protein 3. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1,but no other structural homologies between the 2 genes could be found.

Purified recombinant fragment of GATA3 (aa175-388) expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000

1. Cancer Res. 2005 Dec 15;65(24):11259-64. ; 2. J Histochem Cytochem. 2006 Feb;54(2):161-9. ; 3. Int Arch Allergy Immunol. 2006;139(4):306-16.

Monoclonal Antibody

HDR