Mouse Monoclonal Antibody to MLL | ProMab 20179 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MLL

catalog :

20179

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10F8D7

The same clone is also sold as:

Invitrogen: MA5-15380
Abnova: MAB10562
Santa Cruz Biotechnology: sc-101431
OriGene: AM06209SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20179

Title :

Mouse Monoclonal Antibody to MLL

Species :

Human

Clone :

10F8D7;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.

Immunogen :

Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Genet Couns. 2006;17(2):155-9. ; 2. Cancer Genet Cytogenet. 2006 Jul 15;168(2):162-7 ; 3. Leukemia. 2007 Feb;21(2):360-2. Epub 2007 Jan 4.

Type :

Monoclonal Antibody

Aliases :

MLL