Mouse Monoclonal Antibody to IKBKE | ProMab 20174 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to IKBKE

catalog :

20174

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6B4B5

The same clone is also sold as:

Abnova: MAB10591
Santa Cruz Biotechnology: sc-101430
Invitrogen: MA5-15377
OriGene: AM06206SU-N

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20174

Title :

Mouse Monoclonal Antibody to IKBKE

Species :

Human

Clone :

6B4B5;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NF?B is retained in the cytoplasm in an inactive form by the inhibitory protein I?B. Activation of NF?B requires that I?B be phosphorylated on specific serine residues, which results in targeted degra-dation of I?B. I?B kinase a(IKKa), previously designated CHUK, interacts with I?B-aand specifically phosphorylates I?B-aon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKa, IKKßand IKK?(also designated NEMO), and each appear to make essential contributions to I?B phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKaand IKKß. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFa, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of I?Baon Ser32 and Ser36, and in NF?B activation, suggesting that IKK-i may act as an I?B kinase in the immune system.

Immunogen :

Purified recombinant fragment of IKBKE (aa1-257) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Cell. 2007 Jun 15;129(6):1065-79. ; 2. Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13. ; 3. Arthritis Rheum. 2007 Mar;56(3):743-52.

Type :

Monoclonal Antibody

Aliases :

IKBKE