Mouse Monoclonal Antibody to RET | ProMab 20169 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to RET

catalog :

20169

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6E4C4

The same clone is also sold as:

Abnova: MAB10362
OriGene: AM06202SU-N
Invitrogen: MA5-15373
Santa Cruz Biotechnology: sc-101423

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20169

Title :

Mouse Monoclonal Antibody to RET

Species :

Human

Clone :

6E4C4;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

Immunogen :

Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli. ;

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Young HM. Anderson RB. Anderson CR. Auton Neurosci. 2004, May 31,112(1-2):1-14. ; 2. Myers SM. Mulligan LM. Cancer Res. 2004, Jul 1,64(13):4453-63.

Type :

Monoclonal Antibody

Aliases :

RET