Mouse Monoclonal Antibody to SORL1 | ProMab 20164 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to SORL1

catalog :

20164

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7D7B11

The same clone is also sold as:

Abnova: MAB10367
OriGene: AM06198SU-N
Invitrogen: MA5-15369
Santa Cruz Biotechnology: sc-101426
MyBioSource: MBS850606

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20164

Title :

Mouse Monoclonal Antibody to SORL1

Species :

Human

Clone :

7D7B11;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Immunogen :

Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5. ; 2. Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52. ; 3. Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.

Type :

Monoclonal Antibody

Aliases :

SORL1