Mouse Monoclonal Antibody to DDR2 | ProMab 20151 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to DDR2

catalog :

20151

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B11E4

The same clone is also sold as:

MyBioSource: MBS850146
Novus Biologicals: NBP1-28883
Santa Cruz Biotechnology: sc-81707
OriGene: AM06186SU-N
Abnova: MAB10622
Invitrogen: MA5-15356
Abcam: ab63337

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog :

20151

Title :

Mouse Monoclonal Antibody to DDR2

Species :

Human

Clone :

3B11E4;

lsotype :

Mouse IgG2a

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Immunogen :

Purified recombinant fragment of human DDR2 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. Leitinger B. Kwan AP. Matrix Biol. 2006, Aug, 25(6):355-64. Epub 2006 May 26. ; 2. Shyu KG. Chao YM. Wang BW. et al. Hypertension. 2005, Sep, 46(3):614-21. Epub 2005 Aug 8. ; 3. Neale JC. Kenny TP. Gershwin ME. Clin Dev Immunol. 2004, Jun, 11(2):157-63. ;

Type :

Monoclonal Antibody

Aliases :

TKT; MIG20a; NTRKR3; TYRO10