This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to IGF1R-Beta
catalog :
20149
quantity :
100µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3G5C1

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
product information
Catalog :
20149
Title :
Mouse Monoclonal Antibody to IGF1R-Beta
Species :
Human;
Clone :
3G5C1;
lsotype :
Mouse IgG2a
Size :
100µl
Storage :
4?; -20? for long term storage
Description :
IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Immunogen :
Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.
Formulation :
Ascitic fluid containing 0.03% sodium azide.
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
References :
1. Zhu Z. Jiang W. Thompson HJ. Carcinogenesis. 2003, Jul, 24(7):1225-31. Epub 2003 May 9. ; 2. Ling Y. Maile LA. Clemmons DR. Mol Endocrinol. 2003, Sep,17(9):1824-33. Epub 2003 Jun 5.
Type :
Monoclonal Antibody
MW :
96kDa
Aliases :
IGF1R
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
http://www.promab.com
1-866-339-0871
headquarters: USA