Mouse Monoclonal Antibody to FES | ProMab 20148 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to FES

catalog :

20148

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5A11G5

The same clone is also sold as:

Invitrogen: MA5-15353
OriGene: AM06409SU-N
Santa Cruz Biotechnology: sc-81706

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20148

Title :

Mouse Monoclonal Antibody to FES

Species :

Human

Clone :

5A11G5;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Immunogen :

Purified recombinant fragment of FES expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Delfino FJ. Stevenson H. Smithgall TE. J Biol Chem. 2006, Mar 31, 281(13): 8829-35. Epub 2006 Feb 2. ; 2. Durfee WK. Rivard A. J Biomech Eng. 2005, Nov, 127(6):1014-9. ; 3. Vitenzon AS. Mironov EM. Petrushanskaya KA. Neurosci Behav Physiol. 2005, Sep, 35(7):709-14.

Type :

Monoclonal Antibody

Aliases :

FPS