antibody

Mouse Monoclonal Antibody to FGFR4

20145

100µl

monoclonal

mouse

nonconjugated

4H2B10B2

The same clone is also sold as:

• Abnova: MAB10648
• OriGene: AM06181SU-N
• Invitrogen: MA5-15350

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to FGFR4

Human

4H2B10B2;

Mouse IgG1

100µl

4?; -20? for long term storage

FGFR4 (fibroblast growth factor receptor 4) is part of a family of fibroblast growth factor receptors that mediate the biological functions of specific growth factors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. FGFR4 may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Purified recombinant fragment of FGFR4 expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1. Cell Metab. 2005, Oct, 2(4): 209-10. ; 2. Mol Endocrinol. 2006, Nov, 20(11): 2965-75. ;

Monoclonal Antibody

88kDa

TKF; JTK2; CD334; MGC20292