Mouse Monoclonal Antibody to Human P16 | ProMab 20137 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Human P16

catalog :

20137

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5A8A4

The same clone is also sold as:

Invitrogen: MA5-17093

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20137

Title :

Mouse Monoclonal Antibody to Human P16

Species :

Human;

Clone :

5A8A4;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Immunogen :

Purified recombinant fragment of P16 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Bai, F. et al. Mol. Cell. Biol.2003 23, 1269-1277. ; 2. Lowe, S.W. and Sherr, C.J. Curr. Opin. Genet.2003 Dev.13, 77-83.; 3. Sherr, C.J. Nat. Rev. Mol. Cell Biol.2001 2, 731-737.;

Type :

Monoclonal Antibody

Aliases :

Human P16