Mouse Monoclonal Antibody to RSK1 | ProMab 20136 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to RSK1

catalog :

20136

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10B1D7A9

The same clone is also sold as:

OriGene: AM06174SU-N
Abnova: MAB10388

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20136

Title :

Mouse Monoclonal Antibody to RSK1

Species :

Human;

Clone :

10B1D7A9;

lsotype :

Mouse IgG2b

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK proteins possess two separate kinase domains, the C terminal kinase domain and the N terminal kinase domain, separated by a linker region containing a hydrophobic motif. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation.

Immunogen :

Purified recombinant fragment of human RSK1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Alcorta, D.A., et al. 1989. Mol. Cell. Biol. 9:3850-3859. ; 2. Sweet, L.J., et al. 1990. Mol. Cell. Biol. 10: 2413-2417. ;

Type :

Monoclonal Antibody

Aliases :

RSK; HU-1; RSK1; MAPKAPK1A; RPS6KA1