Mouse Monoclonal Antibody to LYN | ProMab 20123 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to LYN

catalog :

20123

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H8D7

The same clone is also sold as:

Santa Cruz Biotechnology: sc-101849
OriGene: AM06164SU-N
Abnova: MAB5531
Invitrogen: MA5-15329

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20123

Title :

Mouse Monoclonal Antibody to LYN

Species :

Human

Clone :

2H8D7;

lsotype :

Mouse IgG2b

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

Immunogen :

Purified recombinant fragment of LYN expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Sakaguchi, A.Y.,et al.Genet. 34: 175. ; 2. Hibbs, M.L.,et al.Biol. 29: 397-400. ; 3. Williams, J.C.,et al.Trends Biochem. Sci. 23: 179-184. ;

Type :

Monoclonal Antibody

MW :

56kDa

Aliases :

JTK8; FLJ26625