Mouse Monoclonal Antibody to IKBKB | ProMab 20113 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to IKBKB

catalog :

20113

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10A2

The same clone is also sold as:

OriGene: AM06154SU-N
Invitrogen: MA5-15319
Abnova: MAB10695

reactivity :

human

application :

western blot, ELISA

product information

Catalog :

20113

Title :

Mouse Monoclonal Antibody to IKBKB

Species :

Human

Clone :

10A2;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Immunogen :

Purified recombinant fragment of IKBKB expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000

References :

1. Azoitei N,et al. Biochemistry. 2005.14;44(23): 8326-36. ; 2. Kumar KA,et al. Neurosci Lett. 2003.10;340(2): 139-42. ; 3. Peet GW,et al. J Biol Chem. 1999 Nov 12;274(46): 32655-61. ;

Type :

Monoclonal Antibody

MW :

43kDa

Aliases :

IKBKB