Mouse Monoclonal Antibody to INHA (Inhibin alpha) | ProMab 20106 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to INHA (Inhibin alpha)

catalog :

20106

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A2

The same clone is also sold as:

Invitrogen: MA5-15315
OriGene: AM06151PU-N
Novus Biologicals: NB110-89459-0.025ml
Abnova: MAB10699

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

product information

Catalog :

20106

Title :

Mouse Monoclonal Antibody to INHA (Inhibin alpha)

Species :

Human;

Clone :

4A2;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

INHA (A-inhibin subunit precursor, inhibin alpha subunit ), also called inhibin (alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Immunogen :

Purified recombinant fragment of human INHA expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000

References :

1. Mayo, K.E., Cerelli, G.M., Spiess, J., et al. 1986. Proc. Natl. Acad. Sci. USA 83: 5849-5853. ; 2. GM LM, WF Crowley, Jr, AL Schneyer.1995.J. Clin. Endocrinol. Metab., Oct . 80:3043-3049. ; 3. Knight, P.G. 1996.Front. Neuroendocrinol. 17: 476-509. ; 4. PA Fahy, CA Wilson, AJ Beard, et al. 1995.J Endocrinol Nov.147:271-283.

Type :

Monoclonal Antibody

MW :

40kDa

Aliases :

INHA; inhibin, alpha