This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to 4E-BP1
catalog :
20105
quantity :
100µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
11G12C11

The same clone is also sold as:
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
product information
Catalog :
20105
Title :
Mouse Monoclonal Antibody to 4E-BP1
Species :
Human
Clone :
11G12C11;
lsotype :
Mouse IgG1
Size :
100µl
Storage :
4?; -20? for long term storage
Description :
4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Immunogen :
Purified recombinant fragment of 4EBP1 expressed in E. Coli.
Formulation :
Purified antibody in PBS containing 0.03% sodium azide.
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
References :
1. Pause, A. et al. 1994.Nature. 371:762–767. ; 2. Fadden, P. et al. 1997. J. Biol. Chem. 272:10240–10247. ;
Type :
Monoclonal Antibody
Aliases :
BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316; EIF4EBP1
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
http://www.promab.com
1-866-339-0871
headquarters: USA