Mouse Monoclonal Antibody to 4E-BP1 | ProMab 20104 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to 4E-BP1

catalog :

20104

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B6G10

The same clone is also sold as:

OriGene: AM06149SU-N
Abnova: MAB10436
Invitrogen: MA5-15313

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20104

Title :

Mouse Monoclonal Antibody to 4E-BP1

Species :

Human

Clone :

4B6G10;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.

Immunogen :

Purified recombinant fragment of 4E-BP1 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Pause, A. et al. 1994.Nature. 371:762–767. ; 2. Fadden, P. et al. 1997. J. Biol. Chem. 272:10240–10247. ;

Type :

Monoclonal Antibody

Aliases :

BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316; EIF4EBP1