Mouse Monoclonal Antibody to EphB4 | ProMab 20073 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to EphB4

catalog :

20073

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5B8F7

The same clone is also sold as:

OriGene: AM06124SU-N
Invitrogen: MA5-15286
Abnova: MAB10636

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20073

Title :

Mouse Monoclonal Antibody to EphB4

Species :

Human

Clone :

5B8F7;

lsotype :

Mouse IgG2a

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

EPH receptor B4 (EphB4), with 987-amino acid protein (about 108kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.

Immunogen :

Purified recombinant fragment of EphB4 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. J. Chrencik, A. Brooun, M. Recht. Structure. 2006 Feb;14(2):321-30. ; 2. Qinghua WU, Zhenhe SUO,Bjon RISBERG. Pathol Oncol Res. 2004;10(1):26-33. ;

Type :

Monoclonal Antibody

Aliases :

HTK; MYK1; TYRO11