Mouse Monoclonal Antibody to cTnI | ProMab 20050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to cTnI

catalog :

20050

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A10A12

The same clone is also sold as:

OriGene: AM06110SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20050

Title :

Mouse Monoclonal Antibody to cTnI

Species :

Human

Clone :

3A10A12;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

cTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

Immunogen :

Purified recombinant fragment of cTnI expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19(10):999-1010. ; 2. Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113(6):1333-44. ; 3. Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8. ; 4. Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29(2):271-8. ; 5. Adams JE III, Bodor GS, Davila-Roman VG, et al, Circulation, 1993, 88(1):101-6. ;

Type :

Monoclonal Antibody

Aliases :

CMH7; RCM1; cTnI; CMD2A; TNNC1