Mouse Monoclonal Antibody to RB | ProMab 20032 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to RB

catalog :

20032

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7E4B8

The same clone is also sold as:

OriGene: AM06100SU-N
Invitrogen: MA5-15240
Abnova: MAB10384

reactivity :

human

application :

immunohistochemistry

product information

Catalog :

20032

Title :

Mouse Monoclonal Antibody to RB

Species :

Human

Clone :

7E4B8;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).

Immunogen :

Purified recombinant fragment of human RB expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; IHC: 1/200 - 1/1000

References :

1. Oncogene 19: 562-570. ; 2. Cell 81: 323-330. ; ;

Type :

Monoclonal Antibody

Aliases :

RB; pRb; OSRC; pp110; p105-Rb; RB1