Mouse Monoclonal Antibody to Trim5a | ProMab 20023 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to Trim5a

catalog :

20023

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B11H2

The same clone is also sold as:

OriGene: AM06092SU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20023

Title :

Mouse Monoclonal Antibody to Trim5a

Species :

Human;

Clone :

3B11H2;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Immunogen :

Purified recombinant fragment of human trim5 alpha expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Stremlau, M. Nature 2004.427:848-53. ; 2. Song, B. J Virol. 2005.79(7):3930-7. ;

Type :

Monoclonal Antibody

Aliases :

RNF88; TRIM5alpha