Mouse Monoclonal Antibody to KSHV ORF62 | ProMab 20017 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to KSHV ORF62

catalog :

20017

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5B7B6

The same clone is also sold as:

Abnova: MAB10434
Invitrogen: MA5-14770

reactivity :

Human gammaherpesvirus 8

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20017

Title :

Mouse Monoclonal Antibody to KSHV ORF62

Species :

KSHV

Clone :

5B7B6;

lsotype :

Mouse IgM

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.

Immunogen :

Purified recombinant fragment of human KSHV ORF62 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Chang Y. et al. 1994. Science. 266:1865-1869. ; 2. Russo J.J. et al. 1996. PNAS. 93: 14862-14867. ; 3. Wu L. et al. 2000. J VirolOct; 74(20):9646-54. ;

Type :

Monoclonal Antibody

Aliases :

ORF62