Mouse Monoclonal Antibody to KSHV ORF45 | ProMab 20016 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to KSHV ORF45

catalog :

20016

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D4A5

The same clone is also sold as:

Invitrogen: MA5-14769
Abnova: MAB10433
OriGene: AM06086SU-N

reactivity :

Human gammaherpesvirus 8

application :

western blot, ELISA, immunohistochemistry

product information

Catalog :

20016

Title :

Mouse Monoclonal Antibody to KSHV ORF45

Species :

KSHV

Clone :

2D4A5;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions

Immunogen :

Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.

Formulation :

Ascitic fluid containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

References :

1. Chang Y. et al. 1994. Science. 266:1865-1869. ; 2. Zhu FX. et al. 2002. PNAS. 99: 5573-5578. ; 3. Zhu FX. et al. J Virol. 2003. April (77): 4221-4230. ;

Type :

Monoclonal Antibody

Aliases :

ORF45