Mouse Monoclonal Antibody to BCL-10 | ProMab 20003 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to BCL-10

catalog :

20003

quantity :

100µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F8

The same clone is also sold as:

Abnova: MAB15259
Novus Biologicals: NBP1-51524
OriGene: AM06073PU-N
Invitrogen: MA5-14756

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

20003

Title :

Mouse Monoclonal Antibody to BCL-10

Species :

Human; Mouse

Clone :

4F8;

lsotype :

Mouse IgG1

Size :

100µl

Storage :

4?; -20? for long term storage

Description :

Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Immunogen :

Purified recombinant fragment of human BCL-10 expressed in E. Coli.

Formulation :

Purified antibody in PBS containing 0.03% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1. Willis, T.G., et al. (1999) Cell. 96, 35-45. ; 2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019. ; 3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409 ;

Type :

Monoclonal Antibody

MW :

26kDa

Aliases :

CLAP; Me10; CIPER; c-E10; CARMEN