product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
ACE-2 Antibody (SN0754)
catalog :
NBP2-67692
quantity :
100 ul
price :
469 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
SN0754
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 30
Reference
Hatch C, Piombo S, Fang J, Gach J, Ewald M, Van Trigt W, et al. SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system. Front Cardiovasc Med. 2024;11:1360364 pubmed publisher
Subramaniyan B, Gurung S, Bodas M, Moore A, Larabee J, Reuter D, et al. The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions. Viruses. 2023;15: pubmed publisher
Wang L, Wang S, Wu L, Li W, Bray W, Clark A, et al. PCIF1-mediated deposition of 5'-cap N6,2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023;120:e2210361120 pubmed publisher
Lindqvist R, Benz C, Sereikaitė V, Maassen L, Laursen L, Jemth P, et al. A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses. Viruses. 2022;14: pubmed publisher
Forsyth C, Zhang L, Bhushan A, Swanson B, Zhang L, Mamede J, et al. The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation in Human Lung Cells and Inflammatory Cytokine Production in Human Lung and Intestinal Epithelial Cells. Microorganisms. 2022;10: pubmed publisher
Ireland R, Davies C, Keyser E, Findlay J, Eastaugh L, Laws T, et al. Histopathological and Immunological Findings in the Common Marmoset Following Exposure to Aerosolized SARS-CoV-2. Viruses. 2022;14: pubmed publisher
Xue Y, Yang D, Vogel P, Stabenow J, Zalduondo L, Kong Y, et al. Cardiopulmonary Injury in the Syrian Hamster Model of COVID-19. Viruses. 2022;14: pubmed publisher
Lee R, Li T, Chang S, Chao T, Kuo C, Pan M, et al. Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2. Int J Mol Sci. 2022;23: pubmed publisher
Ramal Sanchez M, Castellini C, Cimini C, Taraschi A, Valbonetti L, Barbonetti A, et al. ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa. Int J Mol Sci. 2022;23: pubmed publisher
Zeng F, Li Y, Deng Z, He J, Li W, Wang L, et al. SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes. EMBO Mol Med. 2022;14:e14844 pubmed publisher
Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka M, Niiyama M, et al. ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nat Commun. 2021;12:6791 pubmed publisher
Tu W, McCuaig R, Melino M, Rawle D, Le T, Yan K, et al. Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication. Cell Discov. 2021;7:37 pubmed publisher
Miličić Stanić B, Maddox S, de Souza A, Wu X, Mehranfard D, Ji H, et al. Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19. Am J Physiol Regul Integr Comp Physiol. 2021;320:R925-R937 pubmed publisher
Bhattacharjee M, Lin J, Chang C, Chiou Y, Li T, Tai C, et al. Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2. Mol Biol Evol. 2021;38:2715-2731 pubmed publisher
Suresh V, Parida D, Minz A, Sethi M, Sahoo B, Senapati S. Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies. Front Pharmacol. 2020;11:579330 pubmed publisher
Blume C, Jackson C, Spalluto C, Legebeke J, Nazlamova L, Conforti F, et al. A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection. Nat Genet. 2021;53:205-214 pubmed publisher
Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, et al. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs. Nat Commun. 2020;11:5453 pubmed publisher
Kalidhindi R, Borkar N, Ambhore N, Pabelick C, Prakash Y, Sathish V. Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?. Am J Physiol Lung Cell Mol Physiol. 2020;319:L843-L847 pubmed publisher
Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, et al. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers. medRxiv. 2020;: pubmed publisher
Haydn T, Kehr S, Willmann D, Metzger E, Schüle R, Fulda S. Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells. Int J Cancer. 2020;146:3435-3449 pubmed publisher
Kim D, Nam H, Lee W, Yim H, Ahn J, Park S, et al. PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Mol Cell. 2018;69:398-411.e6 pubmed publisher
Lobo J, Rodrigues A, Antunes L, Graça I, Ramalho Carvalho J, Vieira F, et al. High immunoexpression of Ki67, EZH2, and SMYD3 in diagnostic prostate biopsies independently predicts outcome in patients with prostate cancer. Urol Oncol. 2018;36:161.e7-161.e17 pubmed publisher
Pajtler K, Weingarten C, Thor T, Künkele A, Heukamp L, Buttner R, et al. The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathol Commun. 2013;1:19 pubmed publisher
Kashyap V, Ahmad S, Nilsson E, Helczynski L, Kenna S, Persson J, et al. The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer. Mol Oncol. 2013;7:555-66 pubmed publisher
Serce N, Gnatzy A, Steiner S, Lorenzen H, Kirfel J, Buettner R. Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol. 2012;12:13 pubmed publisher
Janzer A, Lim S, Fronhoffs F, Niazy N, Buettner R, Kirfel J. Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components. Biochem Biophys Res Commun. 2012;421:665-70 pubmed publisher
Bennani Baiti I, Machado I, Llombart Bosch A, Kovar H. Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol. 2012;43:1300-7 pubmed publisher
Schildhaus H, Riegel R, Hartmann W, Steiner S, Wardelmann E, Merkelbach Bruse S, et al. Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors. Hum Pathol. 2011;42:1667-75 pubmed publisher
Kauffman E, Robinson B, Downes M, Powell L, Lee M, Scherr D, et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog. 2011;50:931-44 pubmed publisher
Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis. 2010;31:512-20 pubmed publisher
product information
brand :
Novus
catalog number base :
NBP2-67692
SKU :
NBP2-67692
product name :
ACE-2 Antibody (SN0754)
units size :
100 ul
description :
The ACE-2 Antibody (SN0754) from Novus is a rabbit monoclonal antibody to ACE-2. This antibody reacts with hamster,human,mouse,primate - macaca mulatta (rhesus macaque),rat. The ACE-2 Antibody (SN0754) has been validated for the following applications: IF/IHC,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
ACE-2
category :
Primary Antibodies
buffer :
TBS (pH7.4), 0.05% BSA, 40% Glycerol
clonality :
Monoclonal
clone :
SN0754
concentration :
1 mg/ml
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
host :
Rabbit
immunogen :
Synthetic peptide within Human ACE-2 aa 181-230/ 805. (SwissProt: Q9BYF1 Human; SwissProt: Q8R0I0 Mouse; SwissProt: Q5EGZ1 Rat; SwissProt: A0A1U7QTA1 Hamster)
isotype :
IgG
purity :
Protein A purified
species :
Hamster,Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat
gene symbol :
ACE2
top caption :
Immunohistochemistry-Paraffin: ACE-2 Antibody (SN0754) [NBP2-67692]
applications :
IF/IHC,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
extended description :
Recombinant Monoclonal Antibody.
USD :
469 USD
product details :
Recombinant Monoclonal Antibody.
alt names :
ACEHangiotensin I converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, DKFZp434A014, EC 3.4.17, EC 3.4.17.23, Metalloprotease MPROT15
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.