APP Antibody (6E10) - Chimeric - Azide and BSA Free | Novus Biologicals NBP2-62566 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

APP Antibody (6E10) - Chimeric - Azide and BSA Free

catalog :

NBP2-62566

quantity :

0.2 mg (also 0.025 mg)

price :

499 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

6.00E+10

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 14

Reference
Shen Y, Zaballa S, Bech X, Sancho Balsells A, Rodr xed guez Navarro I, Cifuentes D xed az C, et al. Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming. Cell Stem Cell. 2024;31:1741-1759.e8 pubmed publisher
Sharma B, Torres M, Rodriguez S, Gangwani L, Kumar S. MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons. Neural Regen Res. 2024;19:2698-2707 pubmed publisher
Martín Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, et al. Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model. elife. 2024;12: pubmed publisher
Bose C, Kshirsagar S, Vijayan M, Kumar S, Singh S, Hindle A, et al. The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients. Biochim Biophys Acta Mol Basis Dis. 2024;1870:166932 pubmed publisher
Mowry F, Espejo Porras F, Jin S, Quadri Z, Wu L, Bertolio M, et al. Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice. Neurobiol Dis. 2023;184:106213 pubmed publisher
Kshirsagar S, Bose C, Pradeepkiran J, Hindle A, Singh S, Reddy A. Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166759 pubmed publisher
Fei Z, Pei R, Pan B, Ye S, Zhang R, Ma L, et al. Antibody Assay and Anti-Inflammatory Function Evaluation of Therapeutic Potential of Different Intravenous Immunoglobulins for Alzheimer's Disease. Int J Mol Sci. 2023;24: pubmed publisher
Sheikh A, Yano S, Tabassum S, Mitaki S, Michikawa M, Nagai A. Alzheimer's Amyloid β Peptide Induces Angiogenesis in an Alzheimer's Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions. Int J Mol Sci. 2023;24: pubmed publisher
Jones M, B xfc chler J, Dufor T, Palomer E, Teo S, Martín Flores N, et al. A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease. Sci Adv. 2023;9:eabo7421 pubmed publisher
Lee H, Yoon S, Lee J, Park K, Jung Y, Cho I, et al. Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models. Alzheimers Res Ther. 2022;14:177 pubmed publisher
Rodr xed guez Urgell xe9 s E, Sancho Balsells A, Chen W, L xf3 pez Molina L, Ballasch I, del Castillo I, et al. Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer's Disease. Front Pharmacol. 2022;13:791666 pubmed publisher
Thonda S, Puttapaka S, Kona S, Kalivendi S. Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling. ACS Chem Neurosci. 2021;12:4175-4186 pubmed publisher
Feng B, Freitas A, Gorodetski L, Wang J, Tian R, Lee Y, et al. Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses. Sci Adv. 2021;7: pubmed publisher
Pérez Sisqués L, Sancho Balsells A, Solana Balaguer J, Campoy Campos G, Vives Isern M, Soler Palazón F, et al. RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease. Cell Death Dis. 2021;12:616 pubmed publisher

product information

master code :

NBP2-62566

SKU :

NBP2-62566

product name :

APP Antibody (6E10) - Chimeric - Azide and BSA Free

unit size :

0.2 mg (also 0.025 mg)

description :

The APP Antibody (6E10) - Chimeric - Azide and BSA Free from Novus is a rabbit monoclonal antibody to APP. This antibody reacts with human,mouse,mouse (negative). The APP Antibody (6E10) - Chimeric - Azide and BSA Free has been validated for the following applications: Immunohistochemistry,IF/IHC,ELISA,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Electron Microscopy.

target :

APP

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

6.00E+10

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Amyloid-beta peptide

isotype :

IgG Kappa

purity :

Protein A purified

species :

Human,Mouse,Mouse (Negative)

specificity :

This antibody binds to amino acid residues 1-16 of beta amyloid

gene symbol :

APP

applications :

IF/IHC,ELISA,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Electron Microscopy

extended description :

Recombinant Monoclonal Antibody.

USD :

499 USD

product details :

Recombinant Monoclonal Antibody.

alt names :

amyloid beta (A4) precursor protein-binding, family B, member 2, amyloid beta A4 precursor protein-binding family B member 2, Amyloid beta precursor protein, APP

storage :

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

more info or order :

Novus Biologicals product webpage