EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free | Novus Biologicals NBP2-50599 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free

catalog :

NBP2-50599

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DH8.3

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Novus Biologicals product webpage

citations: 14

Reference
Park D, Bhojnagarwala P, Liaw K, Bordoloi D, Tursi N, Zhao S, et al. Novel tri-specific T-cell engager targeting IL-13Rα2 and EGFRvIII provides long-term survival in heterogeneous GBM challenge and promotes antitumor cytotoxicity with patient immune cells. J Immunother Cancer. 2024;12: pubmed publisher
Sherif O, Khelwatty S, Bagwan I, Seddon A, Dalgleish A, Mudan S, et al. Expression of EGFRvIII and its co‑expression with wild‑type EGFR, or putative cancer stem cell biomarkers CD44 or EpCAM are associated with poorer prognosis in patients with hepatocellular carcinoma. Oncol Rep. 2024;52: pubmed publisher
Park D, Liaw K, Bhojnagarwala P, Zhu X, Choi J, Ali A, et al. Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape. Mol Ther Oncolytics. 2023;28:249-263 pubmed publisher
Lin Y, Hua C, Lu H, Huang S, Chen Y, Tsai M, et al. CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer. iScience. 2023;26:106089 pubmed publisher
Sidorov M, Dighe P, Woo R, Rodriguez Brotons A, Chen M, Ice R, et al. Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment. Cells. 2023;12: pubmed publisher
Welsh J, Killingsworth B, Kepley J, Traynor T, Cook S, Savage J, et al. MPAPASS software enables stitched multiplex, multidimensional EV repertoire analysis and a standard framework for reporting bead-based assays. Cell Rep Methods. 2022;2:100136 pubmed publisher
Kilic T, Cho Y, Jeong N, Shin I, Carter B, Balaj L, et al. Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles. ACS Cent Sci. 2022;8:110-117 pubmed publisher
Banisadr A, Eick M, Beri P, Parisian A, Yeoman B, Placone J, et al. EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration. J Cell Sci. 2020;133: pubmed publisher
Brown C, Amante J, Chhoy P, Elaimy A, Liu H, Zhu L, et al. Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019;51:575-586.e4 pubmed publisher
Plichta Z, Horak D, Marekova D, Turnovcova K, Kaiser R, Jendelova P. Poly[N-(2-hydroxypropyl)methacrylamide]-Modified Magnetic γ-F2 O3 Nanoparticles Conjugated with Doxorubicin for Glioblastoma Treatment. ChemMedChem. 2020;15:96-104 pubmed publisher
Trujillo Alonso V, Pratt E, Zong H, Lara Martinez A, Kaittanis C, Rabie M, et al. FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels. Nat Nanotechnol. 2019;14:616-622 pubmed publisher
Nishikawa R, Sugiyama T, Narita Y, Furnari F, Cavenee W, Matsutani M. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004;21:53-6 pubmed
Jungbluth A, Stockert E, Huang H, Collins V, Coplan K, Iversen K, et al. A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2003;100:639-44 pubmed
Johns T, Stockert E, Ritter G, Jungbluth A, Huang H, Cavenee W, et al. Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer. 2002;98:398-408 pubmed

product information

master code :

NBP2-50599

SKU :

NBP2-50599

product name :

EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free from Novus is a mouse monoclonal antibody to EGFR. This antibody reacts with human. The EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free has been validated for the following applications: ELISA,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry,Immunoprecipitation,CyTOF-ready.

target :

EGFR

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

DH8.3

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.

isotype :

IgG1

purity :

Protein G purified

species :

Human

specificity :

Clone DH8

gene symbol :

EGFR

accessionNumbers :

Q01279

applications :

IF/IHC,ELISA,Flow Cytometry,Western Blot,Immunohistochemistry,Immunoprecipitation,CyTOF-ready

USD :

409 USD

alt names :

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGFR variant III, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ERBB, ErbB1, ERBB1PIG61, HER1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage