Glypican 3 Antibody (GPC3/863) - Azide and BSA Free | Novus Biologicals NBP2-47762 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Glypican 3 Antibody (GPC3/863) - Azide and BSA Free

catalog :

NBP2-47762

quantity :

0.1 mg

price :

349 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GPC3/863

reactivity :

human, rat

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

brand :

Novus

master code :

NBP2-47762

SKU :

NBP2-47762-0.1mg

product name :

Glypican 3 Antibody (GPC3/863) - Azide and BSA Free

description :

The Glypican 3 Antibody (GPC3/863) - Azide and BSA Free from Novus Biologicals is a mouse monoclonal antibody to Glypican 3. This antibody reacts with human, rat. The Glypican 3 Antibody (GPC3/863) - Azide and BSA Free has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence, CyTOF-ready.

target :

Glypican 3

category :

Primary Antibodies

unit size :

0.1 mg

buffer :

10 mM PBS

clonality :

Monoclonal

clone :

GPC3/863

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant full-length human GPC3 protein

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Rat

specificity :

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

theoretical molecular weight :

67 kDa

gene symbol :

GPC3

catalog number base :

NBP2-47762

applications :

Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence, CyTOF-ready

2020 USD :

329

2021 USD :

349 USD

alt names :

DGSX, glypican 3, glypican proteoglycan 3, glypican-3, GTR2-2, heparan sulphate proteoglycan, Intestinal protein OCI-5, MXR7, OCI5, OCI-5, secreted glypican-3, SGB, SGBS, SGBS1SDYS

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.