TRACP/PAP/ACP5 Antibody (ACP5/1070) | Novus Biologicals NBP2-45293 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TRACP/PAP/ACP5 Antibody (ACP5/1070)

catalog :

NBP2-45293

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ACP5/1070

reactivity :

human, rat

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Jin Y, Stohn J, Wang Q, Nagano K, Baron R, Bouxsein M, et al. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone. 2017;97:153-167 pubmed publisher

product information

brand :

Novus

master code :

NBP2-45293

SKU :

NBP2-45293-0.02mg

product name :

TRACP/PAP/ACP5 Antibody (ACP5/1070)

description :

The TRACP/PAP/ACP5 Antibody (ACP5/1070) from Novus Biologicals is a mouse monoclonal antibody to TRACP/PAP/ACP5. This antibody reacts with human, mouse, rat. The TRACP/PAP/ACP5 Antibody (ACP5/1070) has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence.

target :

TRACP/PAP/ACP5

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

ACP5/1070

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant full-length human ACP5 protein

isotype :

IgG2b Kappa

purity :

Protein A or G purified

species :

Human, Mouse, Rat

specificity :

It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.

theoretical molecular weight :

35 kDa

gene symbol :

ACP5

catalog number base :

NBP2-45293

accessionNumbers :

P13686

applications :

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence

2020 USD :

129

2021 USD :

149 USD

storage :

Store at 4C.