HLA DQ Antibody (SPV-L3) | Novus Biologicals NBP2-45041 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

HLA DQ Antibody (SPV-L3)

catalog :

NBP2-45041

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SPV-L3

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 2

Reference
Liao A, Wang C, Weng P, Lin Y, Wang H, Chen H, et al. Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery. JCI Insight. 2020;5: pubmed publisher
Diego V, Luu B, Hofmann M, Dinh L, Almeida M, Powell J, et al. Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A. J Thromb Haemost. 2020;18:201-216 pubmed publisher

product information

brand :

Novus

master code :

NBP2-45041

SKU :

NBP2-45041-0.02mg

product name :

HLA DQ Antibody (SPV-L3)

description :

The HLA DQ Antibody (SPV-L3) from Novus Biologicals is a mouse monoclonal antibody to HLA DQ. This antibody reacts with human, porcine. The HLA DQ Antibody (SPV-L3) has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence.

target :

HLA DQ

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

SPV-L3

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

T4-positive CTL clone HG-38

isotype :

IgG2a Kappa

purity :

Protein A or G purified

species :

Human, Porcine

specificity :

Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.

theoretical molecular weight :

60 kDa

gene symbol :

HLA-DQA1

catalog number base :

NBP2-45041

applications :

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunofluorescence

2020 USD :

129

2021 USD :

149 USD

alt names :

CD, CELIAC1DQ alpha 1 chain, DC-1 alpha chain, DQ-A1, FLJ27088, FLJ27328, GSE, HLA class II histocompatibility antigen, DQ(W3) alpha chain, HLA-DCA, HLA-DQA, leucocyte antigen DQA1, leukocyte antigen alpha chain, major histocompatibility complex, class II, DQ alpha 1, MGC149527, MHC class II antigen, MHC class II DQA1, MHC class II HLA-D alpha glycoprotein, MHC class II HLA-DQ-alpha-1, MHC class II surface glycoprotein, MHC HLA-DQ alpha

storage :

Store at 4C.